2-Chloro-4-pyridinecarboxylic acid is an organic compound with CAS 6313-54-8 and chemical formula C6H4ClNO2. Usually white or light yellow powder with a slight irritating odor. Slightly soluble in water, slightly soluble in ethanol, insoluble in ether. Stable at room temperature, but may decompose under high temperature or exposure to light. The structure contains a free carboxyl unit and a chlorine atom. Due to the electron deficiency of the pyridine ring, this substance can undergo a series of nucleophilic substitution reactions under the attack of strong nucleophilic reagents, resulting in a series of dechlorinated functionalized products. It is a pyridine derivative that can combine with acidic substances to form salts. It can be used as an intermediate in organic synthesis and pharmaceutical chemistry, and is often used for structural modification and synthesis of drug molecules and bioactive molecules. For example, relevant literature has reported that this substance can be used in the synthesis of high camptothecin derivatives with anticancer activity.

2,6-ジクロロイソニアシン is 得られる スルー 塩素化 反応, followed by 塩素化 反応 to 得る 2-}クロロイソニアシン, which is then synthesized through directed dechlorination reaction。

ステップ 1: 塩素化 反応 に 得る 2,6-diクロロイソノニコチン 酸:

(1) 下 適切 反応 条件, react isoniacin with chlorinating agents (such as sulfoxide chloride). The function of a chlorinating agent is to replace the hydrogen atom in isoniacin with the chlorine atom.

(2) 後 the reaction is completed, 2,6-dichloroisonotinic acid is 得られる through appropriate separation and purification methods (such as distillation, crystallization, etc.)。 The product of this step is 2,6-dichloroisonotinic acid。

C₆H₃CLの₂₂ + HCl → 2,6-ジクロロイソニックチン酸 é…¸ 塩酸塩

ステップ 2: 塩素化 反応 に 2-クロロイソニアチン 酸:

(1) 反応 2,6-dichloroisonotinic acid 得られた in the previous step with a chlorinating agent again. This time, the action of the chlorinating agent is to selectively replace one chlorine atom in 2,6-dichloroisononicotinic acid with another chlorine atom, thereby forming 2-chloroisonicotinic acid.

(2) 後 反応 is completed, 2-chloroisonicotinic acid is also 得られる through appropriate separation and purification methods. The product of this step is 2-chloroisonicotinic acid。

2,6-ジクロロイソニアジド 塩酸塩 + HCl → C₆H₄ClNOの₂

ステップ 3: 準備 の 2-chloroisonicotinic acid through directed dechlorination reaction:

(1) 反応 2-クロロイソニック酸 酸 得られた in the previous step with a directed dechlorination agent. The function of directional dechlorination agent is to selectively remove chlorine atoms from 2-chloroisoniacin, それによって 得る the target product 2-クロロイソニアシン。

(2) 後 the reaction is completed, pure 2-chloroisonicotinic acid is obtained through appropriate separation and purification methods. The product of this step is the target 2-Chloro-4-pyridinecarboxylic acid.

C₆H₄ClNOの₂ + 指向性 脱塩素 薬剤 → C₆H₄ClNOの₂

 

私達 are the factory of 2-Chloro 4-ピリジンカルボン酸 酸. 備考: BLOOM TECH(Since 2008), ACHIEVE CHEM-TECH is the subsidiary of us. Our transportation modes include sea transportation, air transportation and land transportation. We prepare various ways to meet the different needs of customers, so as to better serve customers and achieve a win-win situation.

輸送 の 化学 製品 通常 要求 以下 a シリーズ の 安全 規制 および 手順 に 保証 安全 および efficiency during the transportation process. ここ ある some basic steps and cautions for chemical transportation:
1. 理解 交通 規制: 前 開始 輸送, it is 必要 to understand and comply with relevant transportation regulations. These regulations may involve regulations on the transportation of dangerous goods, as well as transportation requirements specific to specific types of chemicals.
2. 選択 適切な 交通 方法: 選択 適切な 交通 方法 基づく the nature, quantity, and transportation distance of the chemical product. The common modes of transportation include land, sea, and air.
3. 準備 輸送 書類: A detailed transportation document needs to be prepared, including a detailed description of the goods, quantity, destination, transportation method, and carrier information. In addition, it is necessary to provide proof of the safety and stability of the goods.
4. 包装 化学薬品: 化学薬品 通常 要求する 特別な 包装 に 保証する safety during transportation. The packaging should comply with the hazardous material packaging and labeling requirements specified by the International Air Transport Association (IATA)。
5. 準拠 with transportation regulations: During transportation, it is necessary to comply with all transportation regulations, including loading, securing, protecting, and preventing leakage of goods. In addition, specific traffic rules and speed restrictions need to be followed.
6. 維持 コミュニケーション: Throughout the transportation process, it is necessary to maintain communication with the carrier and destination in order to promptly address any potential issues.
7. 録音 および 報告: During transportation, all activities and events need to be recorded and reported to relevant departments as needed.
Please note that these steps are only general guidance and cannot replace specific regulations and rules. Before starting transportation, it is best to consult a professional transportation company or organization to ensure compliance with all regulations and rules.

2-クロロ-4-ピリジンカルボン酸 酸 has a wide range of applications in chemistry. The following is a detailed description of all its uses in chemistry:
1. 有機 合成
It is an important intermediate in organic synthesis. It can participate in various organic reactions, such as esterification, amidation, alkylation, etc., thereby constructing various complex organic molecules. By transforming and modifying its functional groups, compounds with different structures and properties can be synthesized, providing rich synthesis routes and strategies for organic synthesis.
2. 分析 化学
それ また has applications in analytical chemistry. It can be used as a fluorescent probe, chromatographic separator, etc. for chemical analysis. For example, by utilizing the fluorescence properties of 2-Chloro 4-ppyridinecarboxylic acid, highly sensitive fluorescent probes can be designed for detecting pollutants in the environment, metabolites in living organisms, and more. In addition, it can also serve as a chromatographic separation agent for the separation and analysis of complex samples.
3. 電気化学
それ また 持っている ある applications in the field of electrochemistry. It can be used as a battery material, capacitor material, etc. for electrochemical energy storage and conversion. For example, by utilizing the redox properties of 2-Chloro 4 pyridinecarboxylic acid, high-performance battery materials can be designed to improve the energy storage density and cycling stability of the battery. で 付加, it can also be used to synthesize capacitor materials, improving the performance and service life of capacitors.

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